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Physiologic dependence definition

Multiple physiological roles for IP6 and the diphosphoinositol polyphosphates have been proposed, including effects on endocytosis and mRNA transport [3] however, definitive evidence for many of these functions is lacking. Such studies are complicated by possible nonspecific effects of this highly negatively charged molecule. Of note is the report of an IP6/IP7-dependent protein kinase activity that phosphorylates pacsin/syndapin I, a protein involved in synaptic vesicle recycling [21]. [Pg.356]

Biomarkers of effect are defined as any measurable biochemical physiologic, or other alteration within an organism that, depending on magnitude, can be recognized as an established or potential health impairment or disease (NAS/NRC 1989). This definition encompasses biochemical or cellular signals of... [Pg.137]

See other pages where Physiologic dependence definition is mentioned: [Pg.112]    [Pg.402]    [Pg.165]    [Pg.160]    [Pg.224]    [Pg.112]    [Pg.177]    [Pg.84]    [Pg.167]    [Pg.251]    [Pg.113]    [Pg.98]    [Pg.223]    [Pg.227]    [Pg.113]    [Pg.326]    [Pg.312]    [Pg.109]    [Pg.160]    [Pg.54]    [Pg.65]    [Pg.253]    [Pg.96]    [Pg.150]    [Pg.83]    [Pg.110]    [Pg.143]    [Pg.67]    [Pg.120]    [Pg.50]    [Pg.68]    [Pg.166]    [Pg.61]    [Pg.39]    [Pg.86]    [Pg.150]    [Pg.99]    [Pg.57]    [Pg.43]    [Pg.59]    [Pg.61]    [Pg.66]    [Pg.76]    [Pg.86]    [Pg.140]    [Pg.494]    [Pg.495]    [Pg.38]    [Pg.108]   
See also in sourсe #XX -- [ Pg.204 , Pg.213 , Pg.288 ]



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Dependence: definitions

Physiological dependence

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