Physicochemical Properties of Amicarbazone

Dissociation constant (20 °C) Amicarbazone has no acidic or basic properties in aqueous solutions. It is not possible to specify dissociation constants for water. 

Solubilities in organic solvents (g L ) (20 °C) n-Heptane 0.07 Xylene 9.2 Poly(ethylene glycol) (Lutrol) 79 Dimethyl sulfoxide 250 Dichloromethane 250 

Research is in most cases a continuous process and takes place in small steps. To better understand the discovery of amicarbazone we should go back to the year 1964 when Dornow published the first examples of the hitherto unknown class of 4-amino-l,2,4-triazin-5-ones [25] (Fig. 10.4). 

Research chemists at the former Farbenfabriken Bayer AG identified these compounds in 1965 as herbicides [57] and specified the mode of action as inhibition of photosystem II [11, 58]. 

The optimization process led in 1966 to the discovery of metribuzin [57] and five years later to metamitron [59], two commercially very successful herbicides for soybeans and sugarbeet, respectively (Fig. 10.5). 

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