Physical principles underlying MIP-ligand recognition

In another study Sellergren and Shea [78] modelled the chromatographic behaviour of a solute, PA, on imprinted and non-imprinted polymers using a simple cation-exchange model, and were able to describe the behaviour as a function of mobile phase pH. Moreover, the model they proposed was sufficient to explain the differences in selectivity between the two polymers. 

The role of template-template self-association in molecular imprinting was the subject of extensive debate during the early work with silica-based systems [1]. Its involvement in organic polymer imprinting has, however, attracted much less 

Although much progress has been made towards the development of a better understanding of the mechanisms underlying molecular imprinting, much remains to be understood. Without doubt, there is much valuable information to be obtained from thermodynamic and spectroscopic studies of the self-assembly, polymerisation and MIP-ligand binding processes. 

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