Physical and Chemical Properties of Active Substance

Declaration of toxicological, ecotoxicological, or environmental significant impurities is needed. Especially hazardous chemicals like, for example, nitrosamines have to be declared and are regulated by a maximum admissible concentration. In this example, the total nitrosamine content of a pesticide formulation must not exceed 1 mg kg of the active substance present. 

Use and declaration of analytical methods have to be in correspondence with the Technical Material and Preparations Guidance for generating and reporting 

These guidelines apply to all studies started after 1 October 1999. 

Where an FAO specification is available for an active substance in a preparation, the tolerance limits must meet those in the FAO specification. However, where there is no appropriate FAO specification, tolerances must meet limits as accepted by the FAO Group of Experts [43, 44]. 

Where an active substance is present as an ester or a salt, the active substance content must be expressed as the amount of the ester or salt present (as the technical material) with a statement dedaring the amount of the active principle. 

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