Phthalazinecarboxylic esters

From Phthalazinecarboxylic Esters with a Grignard Reagent... 

Most of the routes to such amides have been covered already by primary synthesis (Chapter 8), by aminolysis of phthalazinecarboxylic acids (Section 14.1.2), by aminolysis of phthalazinecarbonyl halides (Section 14.2), by aminolysis of phthalazinecarboxylic esters (Section 14.3.2), and by passenger introduction (most chapters). One major and several minor preparative methods are illustrated in the following examples. 

Nl - 6-PHTHALAZINECARBOXYLIC ACID, 3 4-OIHYDRO-l-(HYOROXYMETHYL )-5,7-DIMETHYL-4-0X0- ETHYL ESTER... 

This chapter covers nuclear and extranuclear phthalazinecarboxylic acids, their derivatifes, phthalazinecarbaldehydes, and the ketonic C-acylthalazines. To avoid repetition, the interconversions of these entities are discussed only at the first opportunity for example, the conversion of esters into amides appears as a reaction of esters rather than as a preparative route to amides, simply because treatment of esters precedes that of amides. 

Several reactions of these esters have been covered already reduction to alkylphthalazines (Section 9.2.1), reduction to extranuclear hydroxyphthalazines (Section 11.2.1), conversion into extranuclear hydroxyphthalazines with Grignard reagents (Section 11.2.1), conversion into aminophthalazines by the Curtius reaction reaction (Section 13.2.1), hydrolysis to phthalazinecarboxylic acids (Section 14.1.1), and transesterification (Section 14.3.1). Other reactions are illustrated in the following classified examples. 

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