Photochemotherapeutic agents

An interesting alternative mechanism of activation is the photochemical reduction of Pt(IV) to Pt(II) (Fig. 3). In addition to photoreduction, photosubstitution and photoisomerization can also occur, making the photochemistry of Pt complexes difficult to predict and a careful analysis of the photoproducts imperative (21). We have been involved particularly in the development of photochemotherapeutic agents based on Pt(IV) and the study of their photodecomposition and (subsequent) interactions with... 

Barrett AJ, Kennedy JC, Jones RA, Nadeau P, Pottier RH (1990) The effect of tissue and cellular pH on the selective biodistribution of porphyrin-type photochemotherapeutic agents a volumetric titration study. J Photochem Photobiol B Biol 6 309-323... 

Uses Used in combination with UVA as a photochemotherapeutic agent for treatment of psoriasis, in treatment of vitiligo, and to promote tanning in suntan preps. a major constituent of bergamot oil which is present in some perfumes, fragrances, sunscreens, and food prods. 

Peravaiz, S., Reactive oxygen-dependent production of novel photochemotherapeutic agents, FASEB /., 15, 612, 2001. 

Recently, several groups have focused on the preparation of water-soluble Ceo-star polymers as potential photochemotherapeutic agents for the photodynamic therapy of cancer [45]. 

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