Phosphorylcholine pathways

Deehan, M.R., Frame, M.J., Parkhouse, R.M., Seatter, S.D., Reid, S.D., Harnett, M.M. and Harnett, W. (1998) A phosphorylcholine-containing filarial nematode-secreted product disrupts B lymphocyte activation by targeting key proliferative signaling pathways. Journal of Immunology 160, 2692-2699. 

Figure 6.17. Regulation of organic osmolytes by cells of the inner medulla of the mammalian kidney (after Burg et al., 1997). Thick arrows denote processes that are regulated by changes in osmolality. Activities and/or concentrations of enzymes and transporters involved in uptake and synthesis of osmolytes change slowly relative to activities of leakage pathways. PLase phospholipase, GPC-PDE glycerol phosphorylcholine-phosphodiester-ase.

In addition to being involved in the production of phosphatidylcholine, CDP-choline is also used for the formation of the sphingosine-containing phospholipid, sphingomyelin (Figure 7.1). The major pathway for the formation of sphingomyelin transfers phosphorylcholine from CDP-choline to a ceramide (section 7.4.5 and Figure 7.14). 

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