Phosphorylation Atherton-Todd procedure

The catalysed two-phase adaptation of the Atherton-Todd procedure is effective for the phosphorylation of primary alcohols and of phenols [6] to produce trialkyl phosphates and dialkyl aryl phosphates. Trialkyl phosphates have also be obtained in high yield (>75%) from the alkylation of preformed tctra-n-butylammonium di-/-butylphosphate [7], Subsequent cleavage of the /-butyl groups provide a simple synthesis of monoalkyl phosphates. 

General procedure for the phosphorylation of aminoalcohols using Atherton-Todd reaction (ref Zh. Obshch. Khim., 1974, 46, 21). 

The Atherton-Todd reaction is used to introduce a phosphoryl group in amines, but this procedure encounters difficulties when applied to alcohols. Sonication extended its scope to this last type of substrate (Eq. 26). 

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See also in sourсe #XX -- [ , , , ]

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