Phosphorus oxychloride, dehydration formamides with

Phosphorus oxychloride, dehydration of formamides with, 41, 13, 101 removal from reaction of cyanoacetic acid and phosphorus pentachlo-ride, 41,5,7... 

Dehalogenation of l,l,2-trichloro-2,3,3-trifluorocyclobutane, 43,45 Dehydration of formamides with phosphorus oxychloride to isocyanides, 41, 13, 101... 

Aromatic isocyanides can also be prepared conveniently by the dehydration of the corresponding formamides by phosphorus oxychloride, but much better results are obtained if the reaction is done in the presence of potassium fer/-butoxide rather than pyridine.6 Neither method of dehydrating formamides has yet been used to prepare methyl or ethyl isocyanide because their low boiling points make them difficult to isolate from the reaction mixture hence, until a suitable dehydration procedure is worked out, they are best made by reaction of the corresponding alkyl iodide with silver cyanide. ... 

Dealkylation of tertiary amines with dibenzoyl peroxide, 44, 74 Decarboxylation, intermolecular, of isocyanates to carbodiimides, 43,32 Decker synthesis of amines, 44, 7t, 75 Dehalogenation of l,l,2-trichloro-2,3,3-trifluorocydobutane, 42,45 Dehydration, of formamides with phosphorus oxychloride to isocy-anides, 41, 13, 101 of 4- 2-hydroxyethyl)piperidine to quinuclidine, 44, 90 Dehydrohalogenation of 2-chloroallyl-amines to propargylamines, 44,55 Delepine reaction, to prepare 2-bromo-allylamine, 43, 6 Deoxyanisoin, 40,16 Deoxybenzoin, 40, IT Deoxypiperoin, 40, IT Deaylamine, 41, 8T... 

Successive reduction of l,3-dimethyl-4,5,6,7-tetrahydrobenzo[c]-thiophen-4-one (Section III,C) with sodium borohydride and dehydration of the resulting alcohol with polyphosphoric acid gives the unstable 1,3-dimethyl derivative [(18) R = H] in excellent yield,35 and successive treatment of the same ketone with methylmagnesium iodide and acid gives the 1,3,7-trimethyl derivative [(18) R=Me] (Table IV) and a second compound which is reported to be a dimer. 36 When l,3-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one is treated with a mixture of phosphorus oxychloride and dimethyl-formamide (Vilsmeier-Haack formylation), it gives compound 19, which yields 20 on being treated successively with thioglycolic acid... 

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