Phosphorus Linker Units

TABLE 1.12. Further Examples of Common Sulfur-Based Linker Strategies 

CgHia-Znl, Ni (PPh3)2Cl2, PPh3, LiCL, THF, reflux 

While the most common examples of diversity cleavage using phosphorus linkers have focused on this powerful olefination chemistry, other pertinent examples should be mentioned. Noticeably, cyanophosphoranes can be oxidatively cleaved (ozone or dimethyl-dioxirane) in the presence of a nucleophile (alcohol or amine) to provide a-keto esters and a-keto amides (Table 1.13, Entry 

Finally, the palladium-catalyzed cross-coupling reactions with supported enol phos-phonates were reported by Steel and coworkers (Table 1.13, Entry 1) Polymer-supported lactam enol phosphonates were prepared and multifunctional cleavage was demonstrated, using Suzuki conditions, to provide aryl enamines in good yields. 

---