Phosphorous diamide

Method D The phosphoric diamide (30 mmol), alkylating agent (37 mmol) and TEA-C1 (75 mg, 3 mmol) in aqueous NaOH (50%, 75 ml) are stirred at room temperature for 3 h. The mixture is then diluted with H20 (8 ml) and extracted with CHC1, (3 x 25 ml). The dried (MgS04) extracts are evaporated to yield the monoalkylated derivative. 

Acryhc esters dimerize to give the 2-methylene glutaric acid esters catalyzed by tertiary organic phosphines (37) or organic phosphorous triamides, phosphonous diamides, or phosphinous amides (38). Yields of 75—80% dimer, together with 15—20% trimer, are obtained. Reaction conditions can be varied to obtain high yields of trimer, tetramer, and other polymers. 

A solution of 75 g (Mo mol) of 1,3-propanolamine and 202 g of triethylamine in 100 cc of absolute dioxane Is added dropwise at 25°C to 30°C while stirring well to a solution of 25.9 g (Vio mol) of N,N-bis-( -chloroethyl)-phosphorlc acid amide dichlorlde in 100 cc of absolute dioxane. After the reaction is complete, the product is separated from the precipitated triethylamine hydrochloride and the filtrate Is concentrated by evaporation In waterjet vacuum at 35°C. The residue Is dissolved in a large amount of ether and mixed to saturation with water. The N,N-bis-( -chloroethyl)-N,0-propylene phosphoric acid diamide crystallizes out of the ethereal solution, after it has stood for some time in a refrigerator, in the form of colorless water-soluble crystals. MP 48 C to 49°C. Yield 65% to 70% of the theoretical. 

Chemical Name N,N,0-tris-(/3-chloroethyl)-N -(7-hydroxy-n-propyl)-phosphoric acid ester diamide... 

Labeled phosphoric acid triesters and diamides have been synthesized from phosphoric diimidazolide.tl92],tl93] This method was found to be superior to that involving the dichloridate (phosphoric dichlorides). 

In the third step the methyl group is generated A phosphoric acid diamide created in the third reaction is cleaved under reductive conditions. 

Sasaki, Y., Umetani, S. 2006. Comparison of four bidentate phosphoric and diamide compounds for the extractability of actinides. Journal of Nuclear Science and Technology 43(7) 794-797. 

Das cyclische Diamid I wird durch Ethanol unter milden Bedingungen zum Phosphor-saure-[(2-benzylamino-2-oxo-ethyl)-methyl-amid]-ethylester-phenylester (100%) gespal-ten641 ... 

ErwartungsgemaG reagieren Phosphorigsaure-diamid-ester mit Phenylazid zu Phosphor-... 

Ammonia reacts violently with the oxide, reducing it to red phosphorus. When, however, the ammonia is passed into a solution of the oxide in ether, it gives a diamide of phosphorous acid, HOP(NH2)2. 

CYCLOPHOSPHAMIDUM CYCLOPHOSPHAN CYCLOPHOSPHANE CYCLOPHOSPHANUM CYTO-PHOSPHAN CYTOXAN 2-pi(2-CHLOROETHYL)-AMINO)-l-OXA-3-AZA-2-PHOSPHACYCLOHEXANE-2-OXIDE MONOHYDRATE N,N-DI(2-CHLOROETHYL)-AMINO-N,0-PROPYLENE PHOSPHORIC ACID ESTER DIAMIDE MONOHYDRATE ENDOXANA ENDOX-. N-ASTA ENDOXAN MONOHYDRATE ENDOXAN R ENDUXAN GENOXAL MITOXAN NSC-26271 PROCYTOX SEMDOXAN SENDOXAN SENDUXAN... 

N,N,N -TRIS(2-CHL0R0ETHYL)-N, 0-PR0PYLENE PHOSPHORIC ACID ESTER DIAMIDE see TNT500 TRIS(2-CHLOROETHYL) PHOSPHATE see CG0500 TRIS(P-CHLOROETHYL) PHOSPHATE see CG0500 TRIS-l,2,3-(CHLOROMETHOXY)PROPANE see GGIOOO... 

Extraction processes (TRUEX, PUREX, Talspeak, DIAMEX, PARC, etc.) generally involve complexation of transplutonium elements by alkyl phosphines, phosphine oxides, phosphoric acids, carbamoyl phosphonates, diamides, and thiophosphinates in aqueous/organic extractions, within derivatized solid supports, or on coated particles. There are excellent reviews of the processes and significant complexes by Mathur et al. and selected chapters in The Chemistry of the Actinide and Transactinide Elements to be published in 2003. " Work on the separation for nuclear waste management in the United States, France, and Russia have been reviewed. " ... 

Boron compounds have been used in several ways to achieve reduced flammability of wood products. Borax and boric acid can be incorporated into particle board chips before addition of a dicyan-diamide, phosphoric acid, amino-resin system 85). They can also be used to produce a fire-retardant hardboard. Riem and Dwars 86) added water-soluble ammonium borate to wood fibers before the board was formed. A 6-7% boron content produced a hardboard that had a flame spread of 25 or less. 

Functionalized five- to eight-membered dioxo-l,2-azaphosphacyclanes 129 were prepared by cyclization of dicarbocylic acid diamides and dinitriles with phosphorous acid and phosphorus halogenides followed by hydrolysis (Scheme 78) [173], Such cyclic aminophosphonic acids were suggested as efficient complexing agents for Ca2+ for reduction of aorta calcification (on the rat model) and as hardening retardants for gypsum, etc. 

Trofosfamide, N,N,3-Tris(2-chloroethyl)tetrahy-dro-2H-l, 3,2-oxazaphosphorin-2-amine 2-Oxide 2-[bls(2-Chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-l,3,2-oxaphosphorine 2-oxide N.N.N -tris(2-chlOroethyl)-JV ,0-propylene phosphoric add ester diamide trilophosphamide trophosphamide NSC 109723 Z 4828 Ixoten. CJL.Cl,-NjOjP mol wt 323.56. C 33.41%, H 5.60%, Cl 32.87%, N... 

Several methods have also been described for the preparation of dicyanoacetylene (2) [11]. In our experience the original one [15], which involves dehydration of the diamide 7 of acetyl-enedicarboxylic acid 6 with phosphorous pentoxide [Eq. (2)], is the method of choice if gram quantities of 2 are needed. 

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