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Phosphorothioate deoxynucleotides

Rifai, A.,W. Byrsch, K. Fadden, J. Clark, and K.-H. Schlingensipen. 1996. Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligo-deoxynucleotides in mice. Am. J. Pathol. 149 717-725. [Pg.116]

There has been a further report (see Vol. 25, p. 265) on the use of nucleoside -3 -0-bis (l,l,l,3,3,3,-hexafluoro-2-propyl)phosphites as precursors for other analogues, including H-phosphonothioates and dinucleoside phosphorothioates,227 and the method outlined in Scheme 18 has been used to make di- and oligo-deoxynucleotide phosphorodithioates, with best results in the pyrimidine series.228 The (l p, / p) and (5p, Sp)- diastereomers of the bis-(phosphorothioate) of UpUpU have been prepared in a stereocontrolled manner.229... [Pg.249]

Majumdar, C, Stein, C. A., Cohen, J. S., and Broder, S. (1989) Stepwise mechanism of HIV reverse transcriptase primer function of phosphorothioate oligo-deoxynucleotide. Biochemistry 28,1340-1346. [Pg.186]

Stein, C. A. (1989) Phosphorothioate oligodeoxynucleotide analogues, in Oligo-deoxynucleotides. Antisense Inhibitors of Gene Expression (Cohen, J., ed.) Macmillan Press, London, pp. 97-117. [Pg.205]


See other pages where Phosphorothioate deoxynucleotides is mentioned: [Pg.131]    [Pg.151]    [Pg.131]    [Pg.151]    [Pg.481]    [Pg.217]    [Pg.340]    [Pg.50]    [Pg.359]   
See also in sourсe #XX -- [ Pg.13 , Pg.131 ]




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