Phosphoric 1,2,4-triazolides

The following phosphorous triazolides, can also be used for this polycondensation. The most suitable triazolide, however, is the phosphorous acid diethyl ester triazolide because of an easy work-up of the reaction mixture.1281... 

If the nucleoside is treated with a threefold excess of phosphoryltristriazole and subsequently with a mixture of triethylamine and water, the ionic nucleotide phosphoric triazolide can be obtained [46]... 

The phosphitylation of D-mannose with phosphorous triazolides has afforded primarily the mannofuranose 2,3,6-O-phosphite 12. The complexes formed separately between o-fructose and L-sorbose with 1,10-phenanthroline and Co(III) ions have been characterised, while composites prepared by the reaction of simple sugars with tetraethoxysilane and water have been shown to be capable of resolving racemic cobalt and chromium ion complexes. Sodium alkoxide salts of free sugars have been treated with ferric chloride to give iron-sugar complexes and five-fold deprotonated D-mannose forms dinuclear metalates [X2(P-D-Man-/)2] of trivalent (X = Fe, V, Cr and Al) with O-1,2,3,5 and 6 involved in complexation. ... 

Polycondensation of amino acids with phosphorous diester triazolide are described in references [28] and [53]. Below 80 °C, no racemization was found. 

Other polypeptides obtained by polycondensation with phosphorous diester triazolides are N6-Z-polylysine,[28] Na-Z-isopolylysine,t281 and the sequence polypeptides from /J-Ala-/J-Ala-Gly.l53]... 

Sequence polypeptides were obtained by polycondensation of tauryl peptides and 3-aminopropansulfonylpeptides with the two phosphorous acid diester triazolides A and B [54]... 

Fluorophosphates (phosphorfluoridates), which are important for backbone modified oligonucleotides in molecular biology, are generally synthesized from phosphoric imi-dazolides or triazolides and acylfluorides. In these reactions, for example, the azole group (of the phosphoric or phosphinic imidazolide) is substituted by a fluorine atom, forming an acylazole compound as by-product.[202],[2033... 

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