Phosphoramidites matched

Scheme 7.10. Enantioselective 1,4-addition of Et2Zn to cyclohexenone with Cu(OTf)2-matched (S, R, R)-18 and Cu(OTf)2-mismatched (S, S, S)-18 phosphoramidites.

Yaren et al. described the synthesis of carbocyclic exo-amino nucleoside phosphoramidites (38) and the incorporation of them into oligomers. Their base-pairing properties were investigated and the results showed such analogues engage in specific interactions with natural bases in DNA duplexes. In addition they can form self-pairs that match or exceed the stability of Watson-Crick base-pairs. Therefore, these nucleosides may have applications in biotechnology. 

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