Phosphoramidite complex, catalysis with

Alexakis also studied the enantioselective domino reactions catalyzed by a Cu complex of phosphoramidite 28. The 1,4-addition products of this reaction can be employed in an enolate trapping with vinyl oxiran 40 with Pd(0) catalysis (Scheme 11.9) [18]. This domino process afforded the known precursor 43 in the synthesis of the anticancer agent clavularin B (44) [19]. 

Alexakis developed the enantioselective domino reaction catalyzed by a Cu complex of phosphoramidite 45 using activated allylic compounds 47 with both leaving and electron-withdrawing groups. These designed electrophiles 47 could worked well even without Pd(0) catalysis (Scheme 11.10) [20]. 

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