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Phosphonium coupling direct amination

PHOSPHONIUM COUPLING FOR DIRECT AMINATION 2.3.1 Direct Amination... [Pg.33]

In 2004-2005, the first phosphonium coupling of tautomerizable heterocycles and amines was reported to enable the direct amination reaction. [Pg.33]

In recent years, direct amination of tautomerizable heterocycles with amines via phosphonium coupling has been widely utilized in the synthesis of various heterocychc compounds used for chemical building blocks or medicinal chemistry. The reaction rate of the direct amination is usually dependent upon the electronic and steric nature of the amine nucleophiles. In principle, electron-richer and sterically less-hindered alkyl amines are much more reactive than aryl amines and nitrogen heterocycles (04AP702,05JOC1957). [Pg.34]

See other pages where Phosphonium coupling direct amination is mentioned: [Pg.32]    [Pg.56]    [Pg.77]    [Pg.1983]    [Pg.563]    [Pg.727]    [Pg.301]    [Pg.288]    [Pg.330]    [Pg.298]    [Pg.77]    [Pg.21]    [Pg.498]    [Pg.99]    [Pg.101]    [Pg.101]    [Pg.102]    [Pg.258]   
See also in sourсe #XX -- [ Pg.33 , Pg.35 ]



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