Phospholipid acyl chain conformational disorder, quantitative determination

The quantitative determination of phospholipid acyl chain conformational disorder in hydrated systems of dipalmitoylphosphatidylcholine (DPPC), dipalmitoylphosphatidylethanolamlne (DPPE), mixtures containing DPPC and cholesterol, and mixtures of DPPC and Gramicidin D has been made using FT-IR. The... [Pg.24]

An additional example for the usefulness of IR spectroscopy in studying drug interactions with phospholipid vesicles is the quantitative determination of acyl chain conformation in gramicidin-DPPC mixtures [63]. The technique provides a quantitative measure of the extent to which membrane-spanning peptides induce disorder of phospholipid gel phases and order in liquid crystalline phases. [Pg.78]

RA. Quantitative determination of conformational disorder in the 38. acyl chains of phospholipid bilayers by infrared spectroscopy. Biochemistry 1989 28 8934-8939. [Pg.1015]