Phosphoglycerides chemical synthesis

Plasmalogens are a group of phosphoglycerides which are phosphorylated derivatives of 1-alk-cw-l-enyl-2-acyl-5n-glyceroL The similarity in properties between plasmalogens and the corresponding 1,2-diacyl phospholipids has made isolation procedures difficult. Moreover, chemical synthesis is made... 

Another important feature of biological molecules is their stereochemistry. In lipids based on glycerol, for example, there is an inherent asymmetry at the central carbon atom of glycerol. Thus, chemical synthesis of phosphoglycerides yields an equal mixture of two stereoisomeric forms... 

As previously discussed (see p. 338), many important eicosanoids are derived from arachidonic acid. Almost all cellular arachidonic acid is stored in cell membranes as esters at C-2 of glycerol in phosphoglycerides. Release of arachidonic acid from membrane, considered to be the rate-limiting step in eicosanoid synthesis (Figure 12D), results from binding an appropriate chemical... 

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