Phosphoglycerate mutase, function

Phosphoglycerate mutase, which interconverts 2-phosphoglycerate and 3-phosphoglycerate in glycolysis (Fig. 10-3, step c), functions by a similar mecha-... 

Examination of the first partial reaction reveals that the mutase functions as a phosphatase—it converts 2,3-bisphosphoglycerate into 2-phosphoglycerate. However, the phosphoryl group remains linked to the enzyme. This phosphoryl group is then transferred to 3-phosphoglycerate to reform 2,3-bisphosphoglycerate. 

Isomerases rearrange the functional groups within a molecule and catalyze the conversion of one isomer into another. For example, phosphoglycerate mutase converts one structural isomer, 3-phosphoglycerate, into another, 2-phosphoglycerate ... 

The mutase then functions as a phosphatase it converts 2,3-bisphosphoglycerate into 2-phosphoglycerate. The mutase retains the phosphoryl group to regenerate the modified histidine. 

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