Phosphoenolpyruvate sugar chain extension

Generally, syntheses of DAHP, KDO and Neu5Ac are based on chain extension of an appropriate sugar unit electrophiles by a C3 nucleophiles, according to the biosynthetic pathway, shown in Scheme 1. Thus, the reaction of D-erythrose 4-phosphate (13) acting as a C4 electrophile with phosphoenolpyruvate (14, C3 nucleophile) creates DAHP [6]. Mutual relationship to this pathway concerns the biosynthesis of KDO and Neu5Ac, which are produced on the reaction of phosphoenolpyruvate with D-arabinose 5-phosphate (C5 electrophile) or A-acetyl-D-mannosamine 6-phosphate (C6 electrophile), respectively [5,12]. 

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See also in sourсe #XX -- [ , ]

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