Phosphinimines acylation

Preparations of pyridazino[3,4- [l,3]oxazines by ozonolysis of pyrrolo[2,3-b]pyridazine-3-carboxylates and from the reaction of A -(4-ethoxycarbonylpyridazin-3-yl)phosphinimines with acyl halides were described in CHEC-II(1996) <1996CHEC-11(7)737>. A simpler form of the latter approach has now been reported <1994CC2451>, wherein the 1-A -oxide of 3-aminocinnoline-4-carboxylic acid undergoes cyclization with acetic anhydride (Equation 126). The isomeric pyridazino[4,3-, [l,3]oxazines have been prepared in a similar manner (Equation 127) <1997PHA838>. 

Phosphinimines obtained from 1,2-trans 6-0-/ -tolylsulfonylhexopyranosyl azides rearrange to 6-amino-l,6-anhydro-6-deoxyhexoses, which are stable as acylated derivatives. As intermediates, the tosylate salts could be... 

The most important transformations of glycosyl phosphinimines are their behavior on acylation. Depending on the structure of the P=N component (phosphazide or phosphinimine) derived from the azide and the trivalent phosphorus compound, various modes of acylation may occur, as described by Ko-sower et The results are partially contradictory the acylation of... 

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