Phosphine poisoning

CDC hazardous chemical category choking/lung/pulmonary agent 

Inhalation of gas (rare) or ingestion of solid phosphide reacts with gastric HC1 to form phosphine gas, which interferes with enzymes and protein synthesis, primarily in mitochondria of heart and lung cells, causing myofibril necrosis and secondary ionic changes in peripheral small vessels and lungs 

Cardiovascular Gastrointestinal Liver/Biliary tract/Pancreas Nervous 

Arterial press, gen - decreased (hypotension) [ 1 ] Bowel movements - diarrhea Bowel sounds - decreased/absent (ileus, adynamic) Breathing - difficult, acute (acute dyspnea) 

Chest - pain/tightness Consciousness - loss, prolonged (coma) 

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Wilson R et al Acute phosphine poisoning aboard a grain freighter. JGMA 244 148-150, 1980... 

Arsine/phosphine poisoning Upon inhalation there may be a burning sensation in the chest followed by chest pain, but there may be no symptoms at all, leaving the victim unaware that he or she has been exposed. Symptoms of shortness of breath and weakness that is due to a sudden severe anemia may occur. 

Arsine/phosphinepoisoning There is no antidote for Arsine or phosphine poisoning. Do not administer arsenic chelating drugs. Patient may need blood transfusions. 

Osmium tetroxide poisoning, 367-370 Phosphine poisoning, 375-379 Radiation poisoning, 380-383 Ricin poisoning, 384-387 Salmonellosis, 199-202 Shigellosis, 206-209... 

Calcium Phosphide Dust respirator protective gloves and clothing goggles. Remove to fresh air, call a physician and alert to possibility of phosphine poisoning. Flush with water, call a physician and alert to possibility of phosphine poisoning. Flush with water, call a physician and alert to possibility of phosphine poisoning. 

The clinical pictures of both phosphorus and phosphine poisoning are similar, despite the differing routes of intake. It has been intimated that phosphorus toxicity may be due to phosphine, and that phosphorus is converted to phosphine in the liver, or more probably that this reduction would occur via microbially-assisted metabolism within the gastrointestinal tract before absorption. Phosphine has been detected in the flatus of cows. However, although interesting, this merely avoids the issue and does not provide any further understanding of the molecular mechanisms of toxicity. 

HS (mercaplans—rotten egg small), phosphine (poisonous and wormy odour), methane (suffocating), etc. ... 

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