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Phosphine ligands acetylation

The benzoic acid derivative 457 is formed by the carbonylation of iodoben-zene in aqueous DMF (1 1) without using a phosphine ligand at room temperature and 1 atm[311]. As optimum conditions for the technical synthesis of the anthranilic acid derivative 458, it has been found that A-acetyl protection, which has a chelating effect, is important[312]. Phase-transfer catalysis is combined with the Pd-catalyzed carbonylation of halides[3l3]. Carbonylation of 1,1-dibromoalkenes in the presence of a phase-transfer catalyst gives the gem-inal dicarboxylic acid 459. Use of a polar solvent is important[314]. Interestingly, addition of trimethylsilyl chloride (2 equiv.) increased yield of the lactone 460 remarkabiy[3l5]. Formate esters as a CO source and NaOR are used for the carbonylation of aryl iodides under a nitrogen atmosphere without using CO[316]. Chlorobenzene coordinated by Cr(CO)j is carbonylated with ethyl formate[3l7]. [Pg.190]

The effect of the catalyst and the hgands has not been discussed yet however, it plays an important role. For example, by replacing the classical phosphine ligands by a hydrosoluble sulfonated triphenylphosphine (TPPTS), Safi and Sinou carried out a reaction with butadiene monoxide and ethyl acetoacetate in a two-phase aqueous-organic medium.f The recycled water layer containing the catalyst could be reused with very high efficiency for a second reaction. As a matter of fact, the corresponding ethyl ester of the 2-acetyl-6-hydroxy-4-hexenoic acid was isolated in 80% and 87% yield (Z/E = 15 85) after the first and the second reaction, respectively. [Pg.164]

The carbonylation reaction was carried out by mixing an aqueous solution of NaOH with a xylene solution of the Pd(PPh3)4 in the presence of salt, PhCH2NEt3Cl. Tilley reported the synthesis of anthranilic acid using this method. Pd-catalyzed carbonylation of 2-bromoaniline did not afford anthranilic acid 2e (Scheme 6), but N-acetylated 2-bromoaniline la afforded the desired A -acetylanthranilic acid 2a in high yield. Carbonylation of aqueous media under 1 atm pressure in the presence of palladium complexes without phosphine ligand and some bases leads to the formation of aromatic acid. ... [Pg.670]

Brunner et al. [26] synthesized and applied so-called dendrizymes in enan-tioselective catalysis. These catalysts are based on dendrimers which have a functionalized periphery that carries chiral subunits, (e.g. dendrons functionalized with chiral menthol or borneol ligands). The core phosphine donor atoms can be complexed to (transition) metal salts. The resultant dendron-enlarged 1,2-diphosphino-ethane (e.g. 16, see Scheme 17) Rh1 complexes were used as catalysts in the hydrogenation of acetamidocinnamic acid to yield iV-acetyl-phenylalanine (Scheme 17) [26]. A small retardation of the hydrogenation of the substrate was encountered, pointing to an effect of the meta-positioned dendron substituents. No significantly enantiomerically enriched products were isolated. However, a somewhat improved enantioselectivity (up to 10-11% e.e.) was... [Pg.501]

A monophosphine complex is formed when 3 is mixed with three equivalents of a zinc(ii)salphen complex and half an equivalent of Rh(acac)(CO)2 (acac = acetyl acetonate), whereas the assembly based on template 4 and the zinc(n)salphen complexes forms a bis-phosphine rhodium species. In the latter case, the bisphosphine rhodium complex is completely encapsulated by six salphen building blocks. This difference in mono- versus diphosphine ligation to the Rh -center and, to a lesser extent, the difference in electronic features (and thus donating properties of the phosphine) between template ligands 3 and 4, can be used to induce a different catalytic behavior. [Pg.206]

Acetyl ligands, in niobium complexes, C-H BDEs, 1, 298 Achiral phosphines, on polymer-supported peptides, 12, 698 Acid halides, indium compound reactions, 9, 683 Acidity, one-electron oxidized metal hydrides, 1, 294 Acid leaching, in organometallic stability studies, 12, 612 Acid-platinum rf-monoalkynes, interactions, 8, 641 Acrylate, polymerization with aluminum catalysts, 3, 280 Acrylic monomers, lanthanide-catalyzed polymerization,... [Pg.39]


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See also in sourсe #XX -- [ Pg.360 ]




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Phosphine ligand

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