Phosphatidyl nucleoside

Bonaccio, S., Walde, R, and Luisi, P. L. (1994a). Liposomes containing purine and pyrimidine bases stable unilamellar liposomes from phosphatidyl nucleosides. J. Phys. Chem., 98, 6661-3. 

These questions also have a chemical component it would be helpful to understand the relationship between the chemical structure of the monomeric surfactant and the propensity to assemble to giant vesicles. It has been observed that, generally, a small amount of giant vesicles accompanies the formation of normal vesicles. However, this tendency varies strongly from surfactant to surfactant. This situation also occurs in the case of electroformation [2] some surfactants (e.g. fatty acids/soaps, phosphatidyl nucleosides) fail to give giant vesicles by the electro-formation method [3], and in fact the method seems to be restricted to phosphatidylcholine or to lipid mixtures containing phosphatidylcholine. It is fair to say that the relationship between the chemical structure and the propensity to form vesicles is still poorly understood. 

Shuto S, Awano H, Shimazaki N, Hanaoka K, Matsuda A (1996) Nucleosides and nucleotides.150. Enzymatic synthesis of 5 -phosphatidyl derivatives of l-(2 -C-cyano-2-deoxy-P-D-ar i o-pentofuranosyl) cytosine (CNDAC) and their notable antitumor effects in mice. Bioorg Med Chem Lett 6 1021-1024... 

In cases of compounds with both primary and secondary hydroxyl groups, the primary hydroxyl groups are selectively transphosphatidylated. Nucleoside [39], L-ascorbic acid [40], saccharide [41], kojic acid and arbutin [43], and genipin [44], which have secondary hydroxyl groups or phenolic hydroxyl groups in the molecule, are selectively phosphatidylated at the position of the primary hydroxyl group. 

A review on the synthesis of phosphodiesters by the cyclic enediol phosphate method includes syntheses of phosphatidyl sugars and nucleosides. In reports of plenary lectures, Reese has discussed... 

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