Phosgenation in Taxol Chemistry

Zolmitriptan [139264-17-8], antimigraine agent, 5-HT,D-agonist, 236. Intermediates in various synthetic routes to Zolmitriptan are prepared with phosgene, phosgene equivalents, or phosgene derivatives [170, 171]. 

Zopiclone [43200-80-2], anxiolytic, hypnotic, 240. l-Chlorocarbonyl-4-methylpiper-azine, 238, a key intermediate en route to Zopidone, an API having a carbamate structure, is prepared with phosgene [172, 173]. An improved synthesis of this intermediate has been reported by SNPE [174]. 

SSO I 5 Topics on Specific Synthetic Applications of Phosgenation Reactions 

Phosgenation reactions are applied to a variety of synthetic targets. They play a 

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