Phloridzin diabetes

Ikumi, Y., Kida, T., Sakuma, S., Yamashita, S. and Akashi, M. (2008) Polymer—phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na+ /glucose cotransporter (SGLT1) in the small intestine. Journal of Controlled Release, 125 (1), 42—49. 

Phloridzin (74) was first found in 1835. This dihydrochal-cone occurs in the bark of apple trees, apparently confers disease resistance on the plants, and has been involved in some allelopathic problems. Phloridzin is a feeding stimulant to some insects (Staler, 1986). When ingested by humans, phloridzin impairs reabsorption of glucose by the kidneys and produces a diabetes-like condition (i.e., excess sugar in the blood and urine) (McClure, 1975). 

Masumoto S, Akimoto Y, (Dike H, Kobori M. Dietary phloridzin reduces blood glucose levels and reverses sgltl expression in the small Intestine in streptozotocin-induced diabetic mice. J Agrio Food Chem. 2009 57(11) 4651—4656. 

Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D (2004) Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. Diabetes 53 2901... 

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