Phlegmacin Group

Phlegmacin (371) and its methyl ether (372) have proved of value in the taxonomy of Phlegmacium where they are each representative of two different groups of closely related fungi 515, 617). As in pre- 

It is interesting to note from Table 35 that phlegmacin (371) is produced by the various species of Cortinarius with differing degrees 

From fruit bodies of Cortinarius auroturbinatus an interesting te-tramer has been isolated for which structure (376) has been proposed 515). Due to restricted rotation about the central C-C bond the pigment was isolated in the form of two rotational isomers. 

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It can be summarised that the different methods of kinetic resolution and the synthetic correlations have led to the determination of stereochemistry at the biaryl linkage of atrivirin and flavomannin derivatives. Because the position and shape of the CD couplet around 275 nm is not much influenced by substituents present in the two halves of the dimers (refs. 3, 23), several other pigments can now be correlated. It will however need the development of further methods to elucidate the stereochemistry of the phlegmacin group and to determine the configuration of the chiral centers located in the alicyclic rings of the dimers. 

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