Phenyl-n-ferf-butylnitrone

Milatovic, D., Zivin, M., Hustedt, E., et al., 2000b. Spin trapping agent phenyl-N-ferf-butylnitrone prevents diisopropylphosphorofluoridate-induced exci-totoxicity in skeletal muscle of the rat. Neurosci. Lett. 278,25-28. 

Miyajima, T., Kotake, Y, 1997. Spin trap phenyl N-ferf-butylnitrone (PBN) for the inhibition of nitric oxide synthase induction in mice. Free Radic. Biol. Med. 22, 463-470. 

Yang 1981). Support for the theory of alkyl radical transfer was provided by Ortiz de Monellano et al. (1983) who used the electronic paramagnetic resonance spin-trapping technique to detect the 2-phenylethyl radical formed during microsomal biotransformation of phenelzine. Production of the a-(4-pyridyl 1 -oxide)-N-ferf-butylnitrone/2-phenyl-ethyl radical adduct was dependent on the presence of active microsomes, phenelzine, NADPH (or NADH), and spin trap a-(4-pyridyl l-oxide)-N-ferf-butylnitrone (Ortiz de Monellano et al. 1983). The addition of catalase and superoxide dismutase resulted in a 28.5 and 24 % decrease in radical production, respectively (Rumyantseva et al. 1991). The concentration of the a-(4-pyridyl l-oxide)-N-ferf-butylnitrone/2-phenylethyl radical adduct decreased significantly in the presence of metal chelators, i.e. EDTA, diethylenetriaminepentaacetic acid (DTPA), or deferoxamine mesylate. 

---