1-Phenyl-3-azabicyclo nonanes

Displacement of the nitrogen from its morphan position, as in the 1-phenyl-3-azabicyclo[3.3.1]nonanes (29), afforded compounds without MW analgesic activity, but where, again, some antagonist activity was detected.(22)... 

Phenylsulfenyl bromide also induces transannular ring closure in unsaturated amines35. Thus, treatment of l,2,3,4,7,8-hexahydroa7ocine (4) with phenylsulfenyl bromide yielded 4-phenyl-thio-l-azabicyclo[3.3.0]nonane (5) in 71 % yield together with a small amount of 4-bromo-l-aza-bicyclo[3.3.0]nona ne3 3. 

It , 61 , 91 )- and (lJ , 6J , 9Sw)-8-Benzyl-4-etliyl-5-mctliyl-9-phenyl-3,7-dioxa-8-azabicyclo 4.3,0 nonan-2-one93 ... 

Cyclo-octa-1,5-diene is converted into 9-phenyl-9-azabicyclo[3,3.1] nonane (80%) by reaction with aniline and mercuric acetate followed by dem< rcura-tion. " The diene adds iVN-dibromotoluene-p-sulphonamidc to give (264) ... 

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