Phenyl-acetic acid carbinol

Benzylic Reactivity. 2,5-Dimethyl-3,4-dinitrothiophen has been condensed with aromatic aldehydes to give 3,4-dinitro-2,5-distyryl-thiophens. " An improved synthesis of 3-nitro-2-styryl-thiophens involves bromination of 3-methyl-2-nitrothiophen with A-bromosuccinimide, followed by a modified Wit-tig reaction. From 2,5-di(chloromethyl)thiophen, the phosphonate was prepared by the Arbusov reaction, which was used for the preparation of 2,5-distyryl-thiophens. Trichloromethyl(thienyl)carbinols have been converted into the corresponding fluoro-derivatives through the reaction with phenyl-tetrafluorophosphorane. The liquid-phase catalytic oxidation of phenyl-(2-thienyl)methane in acetic acid in the presence of cobalt(ll) acetate and sodium bromide has been investigated. ... 

Acetyl chloride acephate, azaconazole, chlorfenvinphos, cyhalotrin, dimethomorph, dinoseb acetate, fenitropan, fluxofenim, furconazole, mefluidide, propiconazole Acetyl chloride (dichloro) see dichloro Acetyl chloride phenyl carbinol bromadiolone Acetylene aldrin, 2,4 DB Acetyl hydrazine metamitron Acetylide (sodium) pronamide Acetyl magnesiun bromide empenthrin Acetyl morpholine dimethomorph Acetyloxy propionaldehyde furmecyclox Acrolein 8 hydroxy quinoline sulfate Acrylic acid propaquizafop Acryloyl chloride propaquizafop Acrylonitrile fenpiclonil, fludioxonil, nipyraclofen Aldrin dieldrin, endrin... 

The carbinol precursor of propoxyphene is made by treating the Mannich base 21a with a benzyl Grignard reagent. The major (a) diastereoisomer 21b is separated, resolved with (+)-camphor-10-sulfonic acid, and finally acylated to yield the active drug. Pyrrolidino analogs of propoxyphene are more potent than the parent (acetate, 2 x, propionate,1 x pethidine in mice),(51) while the halogenated acetates 22 (X = F or Cl) have similar activities to morphine in mice.(58) Replacement of terminal phenyl of propoxyphene by 2-pyridyl achieves a potency rise, as occurs also in the cyclic analog 23/59 ... 

Under treatment with strong acid, 2-furyl(phenyl)carbinol 268 and acetate 269 recyclized into cyclopentenone 270 the related a]kyl(furyl)carbinols gave product of dehydration [84],... 

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