Quinidine Phenprocoumon

Quinidine did not alter the anticoagulant effect of warfarin in a study in patients, nor in a retrospective analysis of patient data. However, isolated reports of increased warfarin effects and bleeding have been reported, although these stem from over 35 years ago, and nothing further seems to have been reported, su esting that an interaction is unlikely. Quinidine did not alter the half-life of phenprocoumon in healthy subjects. A small decrease in the effects of dicoumarol and warfarin has also been reported with quinidine, which was attributed to changes in haemodynamic factors following cardioversion. 

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