Phenothiazines glaucoma with

Phenothiazines tend to have antimuscarinic properties and are therefore contraindicated for use in patients with closed-angle glaucoma. Antimuscarinics are contraindicated in closed-angle glaucoma as they may worsen the condition. 

Relative history of seizure disorder, bipolar disorder (may induce mania), urinary retention, narrow-angle glaucoma, delirium, hyperthyroidism, bradycardia (or drugs that cause bradycardia), or electrolyte disturbance (esp. K+ or Mg ). Use caution in conjunction with other antidepressants (including MAOIs and SSRIs), other anticholinergic medications, drugs that increase plasma levels (phenothiazines, haloperidol, cimetidine), or drugs that lower seizure threshold (esp. tramadol). Use caution in elderly, children/adolescents. 

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