Phenothiazine 5-oxides synthesis

Phenols, pAfa values of 586-589 Phenothiazine oxides, mass spectra of 130 2-Phenylsulphinyl-l-indanols, synthesis of 256... 

Iodylbenzene in hot nitrobenzene effected some oxidations mimicking its isoelec-tronic ozone. Among them, the most interesting was with pyrene which was converted into a mixture of three isomeric pyrenequinones this method was advantageous for the preparation of the 4,5-isomer, despite its low yield (14%) [7]. The system iodylbenzene and catalytic amounts of vanadyl acetylacetonide was used for the synthesis of some quinone-imines from phenothiazines and related heterocycles also iV-phenyl-phenylsulphonamide was converted into N-(phenylsulphonyl)-1,4-benzoquinone-imine. 

Chlorinated thiazines, synthesis and dehalogenation of 85S586. Dihydrothiazine N-oxides in synthesis of unusual sugars 86BSB1021. Oxo- and thioxo-l,3-thiazines, synthesis and properties 86KGS3. Phenothiazines, IR spectra of 83H(20)283. 

Downard et al. [123] reported the synthesis of thin films based on the oxidative electropolymerization of substituted pyrroles. The films contained redox couples involving pyrrole derivatives of either the chromophore [Ru(2,2 -bipyridine>3], the electron transfer acceptor paraquat, or the electron transfer donor phenothiazine. 

Polymer-modified electrodes that are prepared by electropolymerization of monomers, with mediating properties toward NADH oxidation, are attractive because the synthesis is irreversible, the long-term stability of the electrode is enhanced, and the catalytic properties of the monomer are retained. A diversity of reports on electropolymerization of o-quinone derivatives [87-89], and phenothiazine and phenoxazine derivatives with different levels of utility for practical applications, can be found in the literature [62,65,66,68,72,90-92], Electropolymerization of azinc derivatives has mainly been reported on gold [66,91], platinum [93], glassy carbon electrodes [65,68,71,81,92,94-97], and other carbonaceous electrode materials (Toray paper [98-100], graphite [101], and screen-printed carbon [70]). 

Additional evidence has been presented in support of hydro-aromatic species, e.g. (82), as intermediates in the thermolysis of aryl 2-azidophenyl sulphides, leading to phenothiazines (Vol. 2, p. 780). A successful synthesis of 117-phenothiazin-l-one (83), a member of a novel class of heterocyclic o-quinone-imines, by oxidation of 1-hydroxyphenothiazine in an inert solvent under carefully controlled conditions has been reported. A dominant feature of the chemical behaviour of (83) is its tendency to undergo dimerization to give a rather intractable product, identified tentatively as (84). A multi-step synthesis of l-methyl-2-aminophenothiazin-3-one has also been described. ... 

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