Phenolics plasma protein interactions

The AuNPs placed in DMEM F-12 cell culture media containing 2.5 mM L-gluta-mine, and 15 mM HEPES without phenol red were well-dispersed and stabilized (Rahman et ak, 2013) however, plasma proteins adsorb on the NP surface, making a protein shell called a protein corona (Cedervall et al., 2007 Lynch et al., 2007 Lynch and Dawson, 2008) within 5 min after mixing (AUdlany and Murphy, 2010) (Figure 5.10). This corona is known to influence the size, shape, and surface chemistry of the AuNPs affecting its interaction with biomolecules and cells (Miclaug et al., 2014). 

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