Phenolic compounds, cancer inhibitory

Kampa et al. made the interesting observation that protocatechuic acid, which is found in grapes and red wine from Vitis vimfera (Vitaceae), showed a time- and dose-dependent inhibitory effect on cell growth of T47D human breast cancer cells at low concentrations (108). The phenolic compound is a potent inhibitor of topoisomerase I (109). The plant likely contains some germanacrolides because these sesquiterpenes are known... 

The structures of five new phenolic lipids, 2-(8"Z-eicosenoyl)-6-(8 Z-pentadecenyl) salicylic acid, 2-(9"Z-hexadecenoyl)-6-(8 Z, ll Z-penta-decadienyl) methyl salicylate, 2-(10"Z, 13"Z-nonadecadienoyl)-6-(8 Z, ll Z-pentadecadienyl) salicylic acid, 2-(16"Z-pentacosenoyl)-6-(8 Z-penta-decenyl) salicylic acid and 2-(9"Z-octadecenoyl)-6-(8 Z, ll Z-pentadeca-dienyl) methyl salicylate from the nuts of the cashew, Anacardium occidentale L. were established by Suo et al on the basis of detailed MS and NMR spectroscopy. These compounds showed inhibitory activities on cytochrome CYP3A4. Bai et al synthesized [3p-acetoxy-urs-12-en-28-oyl]-l-monoglyceride and shown that this compound would have a therapeutic potential in the treatment of gastric cancer. 

Wattenberg, L.W., Coccia, J.B., and Lam, L.K.T., 1980, Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasia. Cancer Res., 40 2820. 

Wattenberg LW, Coccia JB, Lam LKT 1980 Inhibitory effects of phenolic compounds of ben-zo(A)pyrene-induced neoplasia. Cancer Res 400 2820-2823... 

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