Phenobarbitone treatment, effect

A3. Adlard, B. P. F., Lester, R. G., and Lathe, G. H., The effect of phenobarbitone treatment of rats and of protein deprivation on the capacity of liver slices to conjugate bilirubin. Biochem. Pharmacol. 18, 59-63 (1969). 

Lock EA, Ishmael J. 1981. Hepatic and renal nonprotein sulfhydryl concentration following toxic doses of hexachloro-1,3-butadiene in the rat The effect of Arcelor 1254, Phenobarbitone, or SKF 525A treatment. Toxicol AppI Pharmacol 57 79-87. 

The effect of varying urinary pH has been used in the treatment of drug overdose by applying forced alkaline diuresis as an adjunct to the treatment of salicylate or phenobarbitone poisoning. The success of the treatment is limited by the extent to which these drugs are distributed, and by the presence of... 

Vakil SD, Critchley EMR, Phillips JC, Fahim Y, Haydock C, Cocks A, Dyer T. The effect of sodium valproate (Epilim) on phenytoin and phenobarbitone blood levels. Clinical and Pharmacological Aspects of Sodium Valproate (Epilim) in the Treatment of Epilepsy. Proceedings of a Symposium held at Nottingham University, September 1975, 75-7. 

Intravenous phenytoin is effective for the treatment of cardiac arrhythmias, but fatal ventricular asystole secondary to i.v. phenytoin has been reported (60 ). Massive overdose from oral Garoin (phenytoin plus phenobarbitone) has produced right bundle branch block (19 ). It has been suggested that the stopping of diphenylhydantoin before anaesthesia for surgery may precipitate atrioventricular or intraventricular conduction defects during the anaesthesia (30 ). 

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