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Phenobarbital, inhibition uptake

Management of lindane poisoning is symptomatic. Diazepam or phenobarbital is used to control convulsions. Cholestyramine or activated charcoal has been utilized to inhibit lindane uptake after ingestion. In more severe poisonings, the serum levels of lindane may be lowered by hemoperfusion over Am-berlite XAD-4. [Pg.1537]

A series of other barbiturates (phenobarbital, barbital, thiopental, pentobarbital at 1 mmol l i concentration inhibit the orotate uptake system without affecting the incorporation of uracil into cellular pyrimidines [287]. While barbituric acid and hexobarbital are less active, phenylethylhydan-toin, chlorpromazine and phenethyl alcohol are extremely active. Phenobarbital also depresses the utilization of orotic acid for the synthesis of cytidine nucleotides in the liver [288]. a-Hexachlorocyclohexane, an inhibitor of the phenobarbital type, was even more effective in depressing de novo cytidine nucleotide synthesis from orotic acid [289]. [Pg.28]

Since many cytochromes P450 are inducible, the amount of reactive oxygen species can increase by the effect of an inducer e.g. halogenated aromatic compounds, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (Al-Bayati and Stohs 1987), lindane (JUNQUEiRA et al. 1986, Videla et al. 1990), or phenobarbital (ScHOLZ et al. 1990). Lindane elicited a dose-dependent enhancement of total oxygen uptake by the isolated perfused rat liver, which was largely inhibited by 0.55 mM desferrioxamine (Videla et al. 1989). [Pg.637]


See other pages where Phenobarbital, inhibition uptake is mentioned: [Pg.499]    [Pg.190]    [Pg.174]    [Pg.74]    [Pg.153]    [Pg.154]    [Pg.414]    [Pg.202]    [Pg.429]   
See also in sourсe #XX -- [ Pg.148 , Pg.149 ]




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