Phenobarbital chemistry

Fig. 11.1. Separation of some xanthine derivatives Column pBondapak C18 (300x4 rim ID), mobile phase acetonitrile - 0.01 M sodium acetate buffer (pH 4.0) (7 93), flow rate 2.0 ml/min, detection UV 254 nm. Peaks 1, 1-methyluric acid 2, 3-methyl xanthine 3, 1,3-dimethyl-uric acid 4, theobromine 5, theophylline 6, B-hydroxy-ethyltheophylline 7, phenobarbital 8, caffeine 9, 8--chlorotheophyl1ine. (reproduced with permission from ref. 56, by the courtesy of Clinical Chemistry)...

Brown, C. A., 8c Black, S. D. (1989). Membrane topology of mammalian cytochrome P-450 from liver endoplasmic reticulum determination by trypsinolysis of Phenobarbital-treated microsomes. The Journal of Biological Chemistry, 264, 4442-4449. 

Podlasek, S. J., and R. A. McPherson. 1989. Streptokinase binds to lactate dehydrogenase subunit-M which shares an epitope with plasminogen. Clinical Chemistry 35 67-73. Ratanasavanh, D., A. Tazi, M. M. Galteau, and G. Siest. 1979. Localization of gamma-glu-tamyltranferase in subcellular fractions of rat and rabbit liver Effect of phenobarbital. Biochemical Pharmacology 28 1363-1365. 

Valenta, J. N., Sun, L., Ren, Y, and Weber, S. G, Solvatochromic study of poly(vinyl chloride) plasticizers and their solutions in chloroform application to phenobarbital partitioning and molecular recognition of phenobarbital. Analytical Chemistry, 69, 3490, 1997. 

Figure 2 Packing diagrams of four of the low-energy-predicted crystal structures of phenobarbital, resulting from CSP searches with G = 1, 2, and 3. Hydrogen bonds are indicated as dashed green lines. Structures are taken from the supplementary information of Ref. 22. (Reproduced from Ref. 22. Royal Society of Chemistry, 2007.)...

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