Phenelzine Chlordiazepoxide

Noninterfering amitriptyline, amobarbital, ampicillin, butabarbital, butalbital, celbenine, chlordiazepoxide, chlorpromazine, clorazepate, desipramine, diazepam, doxepin, ethchlor-vynol, fluphenazine, hydroxyzine, ibuprofen, imipramine, isoniazid, lidocaine, mephobarbital, mesoridazine, methaqualone, methyluric acid, naprotyline, nordiazepam, nortriptyline, oxazepam, pentobarbital, perphenazine, phenelzine, phenmetrazine, phenobarbital, phenylbutazone, phenjdoin, prednisolone, prednisone, procainamide, prochlorperazine, promazine, promethazine, propoxyphene, protriptyline, pyrilamine, secobarbital, thioridazine, thiothixene, timolol, trazodone, triazolam, trifluoperazine... 

Isolated cases of adverse reactions (chorea, severe headache, facial flushing, massive oedema, and prolonged coma) attributed to interactions between phenelzine and chlordiazepoxide, clonazepam or nitrazepam, and between isocarboxazid and chlordiazepoxide have been described. Evidence from clinical trials su ests that there is no interaction between moclobemide and benzodiazepines, although one study found a slight progressive worsening in driving performance. 

A patient with depression responded well when given phenelzine 15 mg and chlordiazepoxide 10 mg three times a day, but 4 to 5 months later developed choreiform movements of moderate severity, and slight dysarthria. These symptoms subsided when both drugs were withdrawn. ... 

Two patients t ng chlordiazepoxide and either phenelzine or isocarboxazid developed severe oedema, whieh was attributed to the use of the combination. ... 

A patient became unconscious and hyperreflexic, with a low blood pressure (100/60 mmHg), increased heart rate (100 bpm), and increased temperature (38.4 C) about 29 hours after taking an overdose of phenelzine and chlordiazepoxide. Another report briefly mentions a case of prolonged coma lasting 3 days in a patient who overdosed with phenelzine and chlordiazepoxide. ... 

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