Phencyclidine withdrawal symptoms

Cognitive decline, depression, anxiety, violent behavior, and weight loss are reported following chronic use of phencyclidine. Prolonged psychosis has been reported, which can mimic acute schizophrenia, and can persist for 4-6 weeks. Tolerance to the psychoactive effects can lead abusers to take increased doses. Psychological dependence has been noted, but no distinct withdrawal symptoms have been reported. 

Opioids (especially methadone and heroin) are the most common cause of serious neonatal drug withdrawal symptoms. Other dmgs for which a withdrawal syndrome has been reported include phencyclidine (POP), cocaine, amphetamines, tricyclic antidepressants, phenothiazines, benzodiazepines, barbiturates, ethanol, clonidine, diphenhydramine, lithium, meprobamate, and theophylline. A careful dmg history from the mother should include illicit drugs, alcohol, and prescription and over-the-counter medications, and whether she is breast-feeding. 

Table 2 Self-reported symptoms after withdrawal of chronic phencyclidine in 68 users...

Rats demonstrate signs and symptoms of withdrawal after 7 days of receiving 45 mg kg day phencyclidine. 

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