Phenazocine

Phenazocine (Prinadol ), 1,2,3,4,5,6-hexahydro-8-hydroxy-6,11-dimethyl- 3-phenethyl-2,6-methano-3-benzazocine hydrobromide, was synthesized at the National Institutes of Health in a search for new analgesics with low addictive liability. Addiction to phenazocine develops more slowly and is less intense when dosages equivalent to morphine are administered chronically for 30 d. The incidence of side effects (respiratory depression, hypotension, and nausea and vomiting) are less with phenazocine than with morphine. 

Phenazocine is administered intramuscularly in doses of 1 to 3 mg every 4 to 6 h. Its depressant effects are potentiated by CNS depressants such as the barbiturates, phenothiazines, and anesthetics so that smaller doses are indicated when these are used concomitantly with the phenazocine. 

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CJH7CIO 103-80-0) see Bendroflumethiazide Moxaverine Phenacemide Phenazocine D-phenylalanine... 

Phenazine methosulfate, cofactor regeneration using, 3 673 Phenazocine, 4 359t Phendimetrazine (Bontril), 3 91 Phenethanolamines, 13 14 Phenethyl alcohol, antimicrobial used in cosmetics, 7 831t... 

Many benzomorphan derivatives with morphine-like potencies or better have a low physical dependence capacity (PDC) in monkeys especially potent members, however, such as phenazocine and the /3-isomers (Table 5.2, Nos. 8 and 16) have high to intermediate PDC properties [5, 63, 68]. Unusual results have been reported. for the enantiomorphs of a-(X) (R = Me, R = = Et) the... 

Post-operative 38 mg equivalent to 10 mg phenazocine None serious some sedation no nausea or vomiting 198... 

The most known narcotics are the opium alkaloids such as morphine, codeine, thebaine, papaverine, noscapine and their derivatives and modified compounds such as nalmorphine, apomorphine, apomopholcodine, dihydrocodeine, hydro-morphone and heroine, also known as diamorphine. Synthetic narcotics share the structural skeleton of morphine and include dextromethorphan, pentazocine, phenazocine meperidine (pethidine), phentanyl, anfentaitil, remifentalin, methadone, dextropropoxyphene, levoproxyphene, dipipanone, dextromoramide, meptazinol and tramadol. Thebaine derivatives are also modified narcotics and include oxycodone, oxymorphone, etorphine, buprenorphine, nalbuphine, naloxone or naltrexone. Narcotics can be semi-synthesized or totally synthesized from the morphine and thebaine model. The compounds serve various purposes in clinical practise. 

Alkylation of (17-5) with phenethyl bromide leads to phenazocine (18-1), a quite potent analgesic that, however, exhibits the same profile of side effects as the classical... 

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