Phenanthridium derivatives

Isometamidium, a phenanthridium derivative (Fig. 5.7), is a veterinary drug effective for the treatment of trypanosomiasis in cattle, horses, buffaloes, and camels. It is administered by intramuscular injection at dosages in the range 0.5-2 mg/kg bw. 

A variety of inhibitors bind to DNA and thereby eliminate its template activity. Notable among these are the intercalating agents, which slip in between base pairs (e.g., the acridines, phenanthridium derivatives), and the an-thracyclines (daunorubicin, doxorubicin, and plicamycin). 

Sanguinarine. Sanguinarine, 13-methyl[ 1,3]benzodioxolo[5,6-c]-l,3-dioxolo[4,5-i]phenanthridium, is a quaternary ammonium salt belonging to the group of BIAs derived and isolated from rhizomes of Sanguinaria canadensis L. (bloodroot) and other poppy-fumaria species, and possesses potent antibacterial, antifungal, antitumor, and anti-inflammatory activities [104-107],... 

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