Phase space, in simulations

The most important source of errors stems from the difficulty of adequately sampling phase space in simulations. The correlation between successive steps in molecular dynamics or Monte Carlo simulations makes the adequate sampling of all regions of phase space with their proper Boltzmann probability difficult to achieve within reasonable simulation times. The number of independent samples is always far smaller than the number of generated configurations. It has been estimated that sampling of phase space can be as limited as only one independent sampled configuration per picosecond of simulation. ... 

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