Phase I Rejection Filters

The following property rules characterize chemicals that are unlikely to bind the ER  

2) The absence of a ring of any type, such as aromatic, alicyclic, etc. 

3) Inorganic compounds - Shi et al. [24] reported that they know of no inorganic chemicals (chemicals lacking carbon) that bind ER and result in endocrine disruption. Although ER binding may be possible in some cell-free systems, these inorganic compounds may be too hydrophilic to cross a cell membrane and 

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