Pharmacology tiagabine

Outside of the evidence-based guidelines, other pharmacologic treatments are commonly used or avoided. For initial treatment of absence seizures, ethosuximide and valproate are commonly used, not only in the United Kingdom, but also in the United States. Zonisamide may be also used for initial treatment of absence and myoclonic seizures. In absence and myoclonic seizures, carbamazepine, oxcarbazepine, gabapentin, tiagabine, and pregabalin should be avoided, as they have been associated with an exacerbation of these types of seizures. 

Pharmacology The precise mechanism by which tiagabine exerts its antiseizure effect is unknown, although it is believed that it blocks GABA uptake into presynaptic neurons, permitting more GABA to be available for receptor binding on the surfaces of postsynaptic cells. 

PHARMACOLOGICAL EFFECTS AND MECHANISM OF ACTION Tiagabine inhibits the GABA transporter, GAT-1, and thereby reduces GABA uptake into neurons and glia. 

The pharmacology in laboratory animals and biochemistr/ provide evidence of the compound s potency and selective mode of action. Tiagabine also possesses some... 

---