Pharmacology of K channels

Numbers in this table refer to ID50 values (50yo inhibition of peak current), measured at 20 mV test potential. Data for ShA2 are from [29], for RCKl, RCK3, RCK4, RCK5 from [20], for RCK2 from [22], for Kvl from [25]. 

S5-S6 loop region in DRKl by the one of NGK2 confers to the recombinant channel the single-channel conductance and TEA sensitivity of NGK2 [47], Thus, a region of approximately twenty amino acids in the primary sequence of K channels controls essential properties of the K channel pore [48]. 

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Zemkowa H (1992) Physiology and pharmacology of K channels. In Anonymous, ed. Potassium in Ecosystems. 23rd Colloquium of the International Potash Institute, Basel, Switzerland, pp. 221-234. 

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