Pharmacology Lipitor Metabolism

I would like pate de fois gras to start followed by beef stroganoff and a double banana split for dessert. Hold the banana  

No problemo. I m in control because now I can measure the concentrations of my Lipitor and its active metabolites. But a glass of red wine will provide additional insurance. 

Reference J. S. Macwan, I. A. lonita, M. Dostalek, and F. Akhlaghi, Develofment and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS), Anal. Bioanal. Chem. 400 423-433 (2011). 

Background It is well known that hypercholesterolemia is a major risk factor in the progression of atherosclerosis, the major cause of cardiovascular diseases. Statins are widely used to treat hypercholesterolemia. The mechanism of action of these drugs is to reduce the endogenous production of cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase. Atorvastatin (ATV, Lipitor) is one of the top-selling prescribed oral medications. The only known adverse effect is skeletal muscle toxicity (myopathy) that may be related to the formation of the lactone of the acidic side chain on the molecule. 

Methods The six analytes were the parent drug (ATV), the active ortho- and para-hydroxy-ATV, and the inactive lactones of each compound. Deuterated (D5) derivatives of each served as internal standards. The analytes, recovered after protein 

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