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Pharmacokinetics absorption/disposition mechanisms

Extrapolation of pharmacokinetic data from animals to humans is not without limitations and should be done carefully, keeping in mind the assumptions that are necessary for such extrapolation. It is important to select an appropriate in vitro or animal model that has relevance to humans. Extrapolation of animal data to humans is not likely to be successful in instances when the pharmacokinetics (absorption or disposition) is species-dependent, when active processes are involved, when drug action (either beneficial or adverse effects) is due to a poorly understood mechanism, or when species dependent mechanisms of tolerance or enzyme induction are present." -" ... [Pg.68]


See other pages where Pharmacokinetics absorption/disposition mechanisms is mentioned: [Pg.147]    [Pg.216]    [Pg.210]    [Pg.145]    [Pg.21]    [Pg.78]    [Pg.78]    [Pg.3]    [Pg.407]    [Pg.281]    [Pg.9]    [Pg.118]    [Pg.13]    [Pg.101]    [Pg.19]    [Pg.197]    [Pg.279]    [Pg.171]    [Pg.41]    [Pg.259]    [Pg.284]    [Pg.122]   
See also in sourсe #XX -- [ Pg.232 ]




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