Pharmacokinetic theory

White, R. E., Manitpisitkul, P., Pharmacokinetic theory of cassette dosing in drug discovery screening, Drug Metab. Dispos. 2001, 29, 957-966. 

In 1937, the pioneering papttrnetics of Distribution of Substances Administered to the Body published (Teorell, 1937). Since then, pharmacokinetic theory has been well developed and matured as an independentdiscipline. Nevertheless, the characterization of drug absorption usually is assumed empirically and lacks physiological signiLcance. Even to date, some absorption processes are still not well understood and adequately deLned. 

Aarons, L. Population pharmacokinetics theory and practice. Br J Clin Pharmacol 1991, 32 669-670. 

Whiting B, Kelman AW, Grevel J. Population pharmacokinetics Theory and clinical application. Clin Pharmacokinet 1986 11 387 101. 

Most pharmacokinetic theory has concentrated on explaining changes in clearance and bioavailability in terms of the parameters of intrinsic clearance, blood flow and fraction unbound [Eqs. (12) and (21)]. Yet the response of a patient to a dose or dosage regimen of a drug is dependent on the patient exposure to the drug, which is best characterized by AUC. Thus, it will be useful to consider the importance of individual parameters such as CLjnt, Q and / in terms of exposure concepts. Consider first an intravenous dose of a drug where from Eq. (7). 

DeVane, C.L. Jusko, W.J. Dosage regimen design. In Pharmacokinetics Theory and Methodology Rowland, M., Tucker, G., Eds. Pergamon Press Oxford, UK, 1986 213-233. 

Whiting, B. Kelman, A.W. Grevel, J. Population pharmacokinetics theory and clinical application. Clin. Pharmacokinet. 1986,11, 387-401. 

White, R.E. Manitpisitkul, P. Pharmacokinetic Theory of Cassette Dosing in Drug Discovery Screening, DrugMetab. Dispos. 29(7), 957-966 (2001). 

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