Pharmacokinetic interactions disposition

Williams, J.A., Hyland, R., Jones, B.C., Smith, D.A., Hurst, S., Goosen, T.C., Peterkin, V., Koup, J.R. and Ball, S.E. (2004) Drug-drug interactions for UDP-glucuronosyltransferase substrates a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metabolism and Disposition, 32 (11), 1201-1208. 

Venkatakrishnan, K and Obach, R.S. (2005) In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine prediction of nonstationary pharmacokinetics and drug interaction magnitude. Drug Metabolism and Disposition ... 

Marked inter-patient variability exists in the pharmacokinetics of intravenous anaesthetics. Factors that can influence drug disposition include the degree of protein binding, the efficiency of the hepatic and renal clearance systems, physiological changes with ageing, disease states, site of operation, body temperature, and drug interactions (premedicants, volatile anaesthetics). 

Booth CL, Pollack GM, Brouwer KL. Hepatobiliary disposition of valproic acid and valproate glucuronide use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions. Hepatology 1996 23(4) 771-780. 

---